INDICATIONS
Indinavir is an antiviral medication in a gang of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying in your body. It is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). Indinavir isn't a cure for HIV or AIDS.
INSTRUCTIONS
Take indinavir exactly as it was prescribed for you. Do not go ahead and take medication in larger amounts, or go on it for longer than recommended because of your doctor. Follow the directions on your prescription label.
This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist in case you have any questions.
Take indinavir with a full glass (8 ounces) of water or skim milk. You might also drink juice, coffee, or tea with this medication. Drink at the very least 6 portions of water every day to avoid kidney stones if you are taking indinavir. Indinavir must be taken on an empty stomach, at the very least 60 minutes before or 120 minutes following a meal.
If you prefer to go ahead and take medication with food, eat just a light meal, like dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.
It is important to use indinavir regularly to have the most benefit. Get your prescription refilled before you run out of medication completely.
To make sure prescription drugs helps your complaint, your blood will need to be tested regularly. Your liver function might also must be tested. Do not miss any scheduled visits to your physician.
HIV/AIDS is normally treated using a combination of different drugs. To best treat your complaint, use all of one's medications as directed by your doctor. Be sure to read the medication guide or patient instructions given each of your respective medications. Do not alter your doses or medication schedule without advice from your physician. Every person with HIV or AIDS should remain under the care of a doctor.
Take the missed dose when you remember and take your following dose on the regularly scheduled time. If you are a lot more than 120 minutes late in taking your indinavir, skip the missed dose and consider the next regularly scheduled dose. Do not take extra medicine to make up the missed dose.
DOSAGE
Usual Adult Dose for HIV Infection
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Usual Adult Dose for Nonoccupational Exposure
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis needs to be initiated as quickly as possible, within 72 hours of exposure, and continued for 28 days.
Indinavir plus ritonavir plus 2 NRTIs is among the alternative regimens recommended for nonoccupational postexposure HIV prophylaxis.
Usual Adult Dose for Occupational Exposure
800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,
or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.
Duration: Therapy must start promptly, preferably within 1 to a couple of hours postexposure. The exact time period of therapy may vary using the institution's protocol.
Liver Dose Adjustments
Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.
Dose Adjustments
Consider reducing the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin is offered concurrently, and decrease the rifabutin dose by half.
Precautions
Strict adherence for the prescribed dose is essential. Patients should not customize the dose or discontinue therapy without consulting their physician.
Adequate hydration (1.5 liters/day) is essential during therapy to lessen the chance of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation might be necessary if nephrolithiasis occurs.
Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.
STORAGE
Store indinavir at room temperature from moisture as well as heat. Keep the capsules within their original container, combined with packet of moisture-absorbing preservative that includes indinavir capsules.
Get emergency medical help when you have all of these signs of a hypersensitive reaction: hives; difficulty breathing; swelling of your respective face, lips, tongue, or throat. Stop taking indinavir and call your doctor at once when you have any of these serious negative effects:
Less serious negative effects can sometimes include:
This isn't a complete list of unwanted side effects while others may occur. Tell your doctor about any unusual or bothersome side effect.
Do not take medicines in case you are allergic to indinavir.
Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines like ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs could cause life-threatening unwanted effects the use of them if you are taking indinavir.
Before taking indinavir, tell your physician if you are allergic to the drugs, or when you have:
If you've all of these conditions, you need a dose adjustment or special tests to soundly take indinavir.
FDA pregnancy category C. This medication might be unhealthy for an baby. Tell your doctor in case you are pregnant or prefer to conceive during treatment. HIV may be passed towards the baby if your mother isn't properly treated while pregnant. Take all of your respective HIV medicines as forwarded to overcome your infection if you are pregnant.
Your name may have to be listed on an antiviral pregnancy registry once you start using medicines.
You should not breast-feed when you are using indinavir. Women with HIV or AIDS must not breast-feed in any respect. Even if your infant arrives without HIV, might even pass herpes towards the baby inside your breast milk.
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