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Precautions

Do NOT use Effexor XR if:

• you happen to be allergic to the ingredient in Effexor XR
• you consider or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine), selegiline, or St. John's wort during the last 14 days
• you consider a fenfluramine derivative (eg, dexfenfluramine), methylene blue, nefazodone, sibutramine, or tryptophan.

Contact your medical professional or doctor straight away if some of these apply to you.

Some medical conditions may talk with Effexor XR. Tell your doctor or pharmacist in case you have any health conditions, particularly when any of the following connect with you:

• if you might be pregnant, likely to conceive, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• in case you have allergies to medicines, foods, and other substances
• if you or possibly a family member features a reputation bipolar disorder (manic-depression), other mental or mood problems, suicidal thoughts or attempts, or alcohol or substance abuse
• in case you have a reputation seizures, heart related illnesses (eg, heart failure, irregular heartbeat), abnormal electrocardiograms (ECGs), a current cardiac arrest, high blood pressure, an overactive thyroid, liver problems, lung problems, kidney problems, stomach or bowel bleeding, blood or bleeding problems, increased eye pressure (eg, glaucoma), central nervous system problems, or metabolism problems
• if you are dehydrated, have low blood sodium levels, or drink alcohol
• if you will be having electroconvulsive therapy (ECT).

Some medicines may communicate with Effexor XR. Tell your medical provider if you consider every other medicines, especially any of the following:

• Certain diet medicines (eg, phentermine, fenfluramine), linezolid, lithium, MAOIs (eg, phenelzine), methylene blue, metoclopramide, nefazodone, rasagiline, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), selegiline, serotonin 5-HT₁ receptor agonists (eg, sumatriptan), sibutramine, SNRIs (eg, duloxetine),St. John's wort, tramadol, trazodone, tricyclic antidepressants (eg, amitriptyline), or tryptophan because severe negative effects, say for example a reaction that could include fever, rigid muscles, blood pressure levels changes, mental changes, confusion, irritability, agitation, delirium, and coma, may occur
• Anticoagulants (eg, warfarin), aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) as the likelihood of bleeding, including stomach bleeding, could be increased
• Diuretics (eg, furosemide, hydrochlorothiazide) as the chance of low blood sodium levels could possibly be increased
• Azole antifungals (eg, ketoconazole) or cimetidine given that they could raise the chance of Effexor XR's unwanted side effects
• Cyproheptadine because it may decrease Effexor XR's effectiveness
• Aripiprazole, haloperidol, phenothiazines (eg, chlorpromazine, thioridazine), or risperidone because the likelihood of their unwanted side effects could possibly be increased by Effexor XR.

This is probably not a complete set of all interactions that will occur. Ask your medical provider if Effexor XR may talk with other medicines which you take. Check together with your doctor before you start, stop, or customize the dose of any medicine.

Important safety information:

• Effexor XR could cause drowsiness, dizziness, or blurred vision. These effects could possibly be worse if you get it with alcohol or certain medicines. Use Effexor XR with caution. Do not drive or perform other possible unsafe tasks unless you know how you respond to it.
• Do not are drinking alcoholic beverages or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Effexor XR without checking with your doctor; it may add to their effects. Ask your friendly phamacist in case you have queries about which medicines could potentially cause drowsiness.
• Several weeks may pass before your symptoms improve. Do NOT take more than the recommended dose, or use for more than prescribed without checking with your doctor.
• Children, teenagers, and the younger generation taking Effexor XR may be at increased risk for suicidal thoughts or actions. Watch all patients having Effexor XR closely. Contact the doctor simultaneously if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual alteration of mood or behavior occur. Contact your physician right away if any signs of suicidal thoughts or actions occur.
• Serotonin syndrome is really a possibly fatal syndrome which can be a result of Effexor XR. Your risk might be greater invest the Effexor XR with certain other medicines (eg, "triptans," MAOIs, SSRIs). Symptoms can include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor simultaneously if you have all of these symptoms.
• Neuroleptic malignant syndrome (NMS) is often a possibly fatal syndrome that may be a result of Effexor XR. Symptoms might include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your physician simultaneously if you have some of these symptoms.
• If your physician informs you to halt taking Effexor XR, you simply must wait for an time period before commencing to look at certain other medicines (eg, MAOIs, nefazodone, thioridazine). Ask your doctor ought to start to consider a new medicines after you have stopped taking Effexor XR.
• Effexor XR may rarely cause a prolonged, painful erection. This could happen even when you happen to be not having sexual intercourse. If this is not treated straight away, it may result in permanent sexual problems including impotence. Contact a medical expert straight away in such a circumstance.
• Lab tests, including hypertension and blood cholesterol, might be performed when you use Effexor XR. These tests might be used to monitor your condition or search for negative effects. Be sure to keep all doctor and lab appointments.
• Use Effexor XR with caution inside the elderly; they may be more understanding of its effects, especially low blood sodium levels.
• Caution is recommended when utilizing Effexor XR in youngsters; they may be more understanding of its effects, especially increased likelihood of suicidal thoughts or actions.
• Effexor XR needs to be used with extreme care in children; safety and effectiveness in children are not confirmed.
• Effexor XR could potentially cause weight changes and growth changes. Children and teenagers may require regular weight and growth checks while they take Effexor XR.

Pregnancy and breast-feeding: Effexor XR may cause trouble for the fetus if it is used during the last 3 months of pregnancy. If you become pregnant, speak to your doctor. You will need to discuss the benefits and risks of using Effexor XR while you are pregnant. Effexor XR is situated in breast milk. Do not breastfeed while taking Effexor XR.