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Precautions

Do NOT use Duetact if:

• you happen to be allergic to your ingredient in Duetact
• you have moderate to severe heart failure, liver problems or abnormal liver function tests, certain severe problems linked to diabetes (eg, diabetic ketoacidosis, diabetic coma), moderate to severe burns, or quite high blood acid levels (acidosis)
• you might have type 1 diabetes
• you are taking bosentan.

Contact your medical professional or health care provider immediately if all of these apply to you.

Some health concerns may talk with Duetact. Tell your medical professional or pharmacist when you have any health concerns, in particular when any of the following apply to you:

• if you happen to be pregnant, planning to become pregnant, or are breast-feeding
• in the event you consider any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• in case you have allergies to medicines, foods, or any other substances
• in case you have had an extreme hypersensitivity (eg, severe rash, hives, the like, dizziness) to the other sulfonamide medicine such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glipizide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide
• in case you have a history of kidney, thyroid, heart, or blood vessel problems; anemia, stroke; certain hormonal problems (eg, adrenal or pituitary problems, syndrome of inappropriate secretion of antidiuretic hormone [SIADH]); low blood sodium levels; or lower levels of an enzyme called glucose 6-phosphate dehydrogenase (G6PD)
• in case you have stomach or bowel obstruction (eg, stomach or bowel blockage, stomach paralysis), are drinking alcohol, or experienced poor nutrition
• in case you have very poor health, an increased fever, a severe infection, severe diarrhea, high blood acid levels, or brain or neurological system problems, or also have an extreme injury
• when you have a history of bladder cancer, bone fracture, low calcium intake, or weak bones (eg, osteoporosis)
• in case you have swelling problems (edema) or certain eye problems (macular edema)
• if you will be having surgery.

Some medicines may interact with Duetact. Tell your health care provider in case you take every other medicines, especially any in the following:

• Bosentan because liver problems may occur, as well as the effectiveness of both medicines could be decreased
• Beta-blockers (eg, propranolol) since the probability of low blood sugar could possibly be increased. They may also hide certain signs of low blood glucose levels and earn it tougher to notice
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), azole antifungals (eg, miconazole, ketoconazole), chloramphenicol, clarithromycin, clofibrate, disopyramide, fenfluramine, fluoxetine, insulin, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), phenylbutazone, probenecid, quinolone antibiotics (eg, ciprofloxacin), salicylates (eg, aspirin), and sulfonamides (eg, sulfamethoxazole) as the risk of low blood glucose levels may be increased
• Calcium channel blockers (eg, diltiazem), corticosteroids (eg, prednisone), decongestants (eg, pseudoephedrine), diazoxide, diuretics (eg, furosemide, hydrochlorothiazide), estrogens, hormonal contraceptives (eg, birth control pills), isoniazid, niacin, phenothiazines (eg, promethazine), phenytoin, rifamycins (eg, rifampin), sympathomimetics (eg, albuterol, epinephrine), or thyroid supplements (eg, levothyroxine) because they may decrease Duetact's effectiveness, resulting in high blood sugar
• Gemfibrozil because blood sugar could possibly be increased or decreased
• Anticoagulants (eg, warfarin) his or her effectiveness may be decreased or perhaps the risk of their side effects could possibly be increased by Duetact.

This is probably not an entire list of all interactions which could occur. Ask your medical provider if Duetact may connect to other medicines that you take. Check with your health care provider before you start, stop, or alter the dose of the medicine.

Important safety information:

• Duetact could potentially cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects could possibly be worse should you go on it with alcohol or certain medicines. Use Duetact with caution. Do not drive or perform other possible unsafe tasks before you recognize how you answer it.
• Do not drink alcohol as you are taking Duetact; it could improve the probability of low blood sugar. Rarely, alcohol may talk with Duetact and result in a serious reaction with symptoms including flushing, nausea, vomiting, dizziness, or stomach pain. Discuss any questions or concerns along with your doctor.
• Carry an ID card always that says you've got diabetes.
• Proper diet and exercise are important so that you can lose fat and them back. Follow the diet and exercise program presented to you from your physician.
• Check your blood glucose levels levels as directed from your doctor. If they are often higher or lower than they should be so you take Duetact exactly as prescribed, tell your medical professional.
• It may be harder to regulate your blood glucose levels during periods of stress including fever, infection, injury, or surgery. Talk using your doctor about how precisely to control your blood sugar levels if some of these occur. Do not change the dose of the medicine without checking with your doctor.
• Do not take greater than the recommended dose without checking along with your doctor.
• Duetact could cause low blood sugar levels. Low blood glucose may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also you could make your heartbeat faster; build your vision change; give you a headache, chills, or tremors; or allow you to more hungry. It is a good plan to transport a dependable source of glucose (eg, tablets or gel) to deal with low blood sugar. If this is not available, you ought to eat or drink a simple way to obtain sugar like ordinary sugar, honey, candy, orange juice, or non-diet soda. This will lift up your blood sugar level quickly. Tell your medical professional immediately should this happen. To prevent low blood sugar levels, eat meals at the same time daily and do not skip meals.
• Risk of low blood glucose levels may be increased by severe or prolonged exercise, alcohol consumption, or skipping meals.
• Duetact includes a sulfonylurea. It may boost the chance of death from cardiovascular disease. Talk using your doctor concerning the benefits and perils associated with this or other therapies to treat your complaint.
• Duetact may cause ovulation ladies that have not reached menopause but do not ovulate. To avoid pregnancy, be sure to use effective contraceptive when using Duetact.
• Duetact could cause you to become sunburned with less effort. Avoid the sun, sunlamps, or tanning booths unless you recognize how you reply to Duetact. Use a sunscreen or wear protective clothing should you should be outside for over a limited time.
• Tell your physician or dentist which you take Duetact when you have any medical or dental hygiene, emergency care, or surgery.
• Duetact could possibly be associated with an increased chance of bladder cancer. Discuss any questions or concerns together with your doctor.
• An increased incidence of bone fracture has become reported in women who take Duetact. Tell your doctor when you have a good reputation for bone fracture, low calcium intake, or weak bones (eg, osteoporosis). Tell your physician straight away if you experience any unusual bone pain.
• Lab tests, including fasting blood glucose levels, hemoglobin A_1c, liver function, and eye exams, could be performed when you use Duetact. These tests might be used to monitor your trouble or pay attention to unwanted side effects. Be sure to keep all doctor and lab appointments.
• Use Duetact with caution inside elderly; they could be more responsive to its effects, specially the risk of cardiovascular disease or low blood glucose.
• Duetact should not be used in children; safety and effectiveness in children haven't been confirmed.
• Pregnancy and breast-feeding: Duetact could cause injury to the fetus or newborn. If you think you might be pregnant, speak to your doctor. You will need to discuss the benefits and perils associated with using Duetact while you might be pregnant. It is not known if Duetact is situated in breast milk. Do not breastfeed while taking Duetact.

When used by long periods of time Duetact might not exactly be well. If your blood sugar levels continues to be manageable after which becomes challenging to manage, contact your doctor. Do not change the dose of the medicine without checking with your doctor.