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Precautions

Do NOT use Depakote if:

• you are allergic to the ingredient in Depakote
• you might have liver problems or perhaps a urea cycle disorder.

Contact your physician or doctor right away if some of these apply to you.

Some medical ailments may talk with Depakote. Tell your physician or pharmacist for those who have any medical conditions, particularly if any in the following apply to you:

• if you're pregnant, planning to conceive, are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• for those who have allergies to medicines, foods, or any other substances
• if you have a good reputation for abusive drinking, liver problems, metabolic disease, blood disease, HIV infection, cytomegalovirus (CMV) infection, high blood amounts of ammonia or glutamine, low temperature, low degrees of albumin, brain problems (eg, organic brain disease), mental retardation, inflammation in the pancreas, kidney problems, or low levels of white blood cells, or if you're scheduled for surgery
• if you have a good reputation for ornithine transcarbamylase deficiency or unexplained coma
• for those who have a family reputation urea cycle disorders or unexplained infant deaths
• when you have a reputation mental or mood problems (eg, depression), or suicidal thoughts or actions
• if you adopt some other medicine for seizures.

Some medicines may interact with Depakote. Tell your medical provider if you take some other medicines, especially any from the following:

• Benzodiazepines (eg, diazepam), carbamazepine, erythromycin, felbamate, fluoxetine, guanfacine, isoniazid, ketoconazole, risperidone, or salicylates (eg, aspirin) because the likelihood of serious negative effects of Depakote, including changes in vision or another vision problems, clumsiness or unsteadiness, drowsiness, nausea, or vomiting, may be increased
• Clonazepam since the chance of seizures could possibly be increased
• Topiramate because the likelihood of high ammonium levels, brain problems, or an unusual drop in body temperature could possibly be increased
• Acyclovir, cancer medicines, carbapenem antibiotics (eg, ertapenem, imipenem, meropenem), cholestyramine, hydantoins (eg, phenytoin), mefloquine, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), oral contraceptives (eg, birth control method pills), or rifampin given that they may decrease Depakote's effectiveness
• Anticoagulants (eg, warfarin), barbiturates (eg, phenobarbital), ethosuximide, lamotrigine, methylphenidate, primidone, tolbutamide, tricyclic antidepressants (eg, amitriptyline), or zidovudine as the likelihood of their unwanted side effects may be increased by Depakote.

This might not be a total report on all interactions that may occur. Ask your medical provider if Depakote may communicate with other medicines that you are taking. Check with your doctor before starting, stop, or affect the dose of any medicine.

Important safety information:

• Depakote might cause drowsiness, dizziness, or blurred vision. These effects could be worse in case you go on it with alcohol or certain medicines. Use Depakote with caution. Do not drive or perform other possible unsafe tasks and soon you understand how you respond to it.
• Do not consume alcohol or use medicines that could potentially cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Depakote; it could increase their effects. Ask your friendly phamacist if you have questions regarding which medicines might cause drowsiness.
• Inflammation in the pancreas is often a potentially life-threatening illness associated with Depakote. Symptoms include stomach pain, vomiting, or decrease of appetite. Contact your medical professional immediately if these symptoms occur.
• Patients having Depakote might be at increased risk for suicidal thoughts or actions. The risk could be greater in patients who have had suicidal thoughts or actions within the past. Patients who may have bipolar (manic-depressive) illness can also provide an increased risk for suicidal thoughts or actions. Watch patients taking Depakote closely. Contact a doctor immediately if new, worsened, or sudden symptoms, like depressed mood; anxious, restless, irritable behavior; anxiety attacks; or any unusual change in mood or behavior occur. Contact a doctor right away if any signs and symptoms of suicidal thoughts or actions occur.
• Depakote may lessen the quantity of clot-forming cells (platelets) with your blood. Avoid activities that may cause bruising or injury. Tell a medical expert for those who have unusual bruising or bleeding. Tell your medical professional if you have dark, tarry, or bloody stools.
• Tell your doctor or dentist that you take Depakote before you decide to have any medical or dentistry, emergency care, or surgery.
• Diabetes patients - Depakote might cause the final results of some tests for urine ketones to get wrong. Ask your physician before you improve your diet or the dose of your diabetes medicine.
• Depakote might increase the ammonia levels inside your blood. Contact your doctor immediately if you experience unexplained sluggishness and vomiting or mental changes.
• Depakote may cause a unique drop in body temperature (hypothermia). Symptoms may include confusion, insufficient energy, lack of coordination, shivering, slow heartbeat, slow or shallow breathing, slurred speech, or unusual drowsiness. Contact your medical professional without delay when you have any of these symptoms.
• Depakote may obstruct certain lab tests, including thyroid function. Be sure your doctor and lab personnel know you consider Depakote
• Lab tests, including complete blood cell counts, blood ammonia levels, and liver function, may be performed while you use Depakote. These tests might be employed to monitor your problem or search for unwanted effects. Be sure to keep all doctor and lab appointments.
• Use Depakote with caution inside the elderly; they may be more sensitive to its effects, especially drowsiness.
• Depakote should be used with extreme caution in children younger than ten years old; safety and effectiveness during these children are not confirmed. Children younger two years could be at increased likelihood of serious liver problems.
• Pregnancy and breast-feeding: Depakote has been shown to cause harm to the fetus. Use an effective way of birth control while you're taking Depakote. If you think you may be pregnant or should you wish to become pregnant, contact your doctor. You will need to discuss the advantages and perils associated with using Depakote while you are pregnant. Depakote is located in breast milk. Do not breastfeed when you are taking Depakote.