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Precautions

Do NOT use Clozaril if:

• you happen to be allergic to the ingredient in Clozaril
• you have bone marrow problems, other blood cell problems, or a reputation blood problems a result of Clozaril
• you've uncontrolled seizures (eg, epilepsy) or loss of bowel muscle movement (paralytic ileus)
• you have severe drowsiness
• you take other medicines that could potentially cause blood problems. Ask your medical professional should you be unsure if all of your medicines could potentially cause blood problems.

Contact your doctor or health care provider right away if all of these connect with you.

Some medical ailments may communicate with Clozaril. Tell your physician or pharmacist if you have any health concerns, particularly when any with the following apply to you:

• if you are pregnant, likely to conceive, or are breast-feeding
• if you take any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• in case you have allergies to medicines, foods, or another substances
• if you have a good reputation for blood clots, blood problems, high blood cholesterol, cardiovascular disease, or lung or breathing problems
• in case you have a history of your enlarged prostate; prolonged, painful erections; liver or kidney problems; seizures (eg, epilepsy); glaucoma; stomach or bowel obstruction; or dementia
• if you have illness, diabetes, or a member of the family with diabetes, or you are very overweight
• when you have decreased activity of enzymes that metabolize certain medicines.

Some medicines may connect to Clozaril. Tell your medical provider if you take every other medicines, especially any from the following:

• Benzodiazepines (eg, lorazepam) and other medicines for mental or mood problems as the probability of heart or breathing problems may be increased
• Cimetidine, erythromycin, quinolone antibiotics (eg, ciprofloxacin), risperidone, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) simply because they might increase the chance of Clozaril's unwanted side effects
• Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), nicotine, or rifampin because they may decrease Clozaril's effectiveness
• Antiarrhythmics (eg, propafenone, quinidine), anticholinergics (eg, benztropine), carbamazepine, debrisoquin, dextromethorphan, medicines for depression or high blood pressure, phenothiazines (eg, chlorpromazine), or tricyclic antidepressants (eg, amitriptyline) for the reason that probability of their side effects might be increased by Clozaril.

This will not be an entire list of all interactions which could occur. Ask your medical provider if Clozaril may connect to other medicines that you take. Check together with your doctor before you begin, stop, or customize the dose of any medicine.

Important safety information:

• Clozaril could potentially cause drowsiness, dizziness, or lightheadedness. These effects could be worse if you get it with alcohol or certain medicines. Use Clozaril with caution. Do not drive or perform other possible unsafe tasks until you recognize how you reply to it.
• Do not use alcohol or medicines that could potentially cause drowsiness (eg, sleep aids, muscle relaxers) while you taking Clozaril. It may enhance their effects. Ask your pharmacist in case you have questions on which medicines could potentially cause drowsiness.
• Clozaril might cause dizziness, lightheadedness, or fainting; alcohol, warm weather, exercise, or fever may increase these effects. To prevent them, crunch or stand slowly, especially within the morning. Sit or sleep the night in the first symbol of any of these effects.
• Clozaril may lower the ability of your body to battle infection. Avoid connection with those who have colds or infections. Tell your medical professional without delay if you notice any signs of infection like fever, sore throat, rash, chills, mouth or nose sores, or unusual tiredness or weakness.
• Women and patients of Jewish background could be at greater probability of developing blood difficulties with Clozaril.
• If you have a history of seizures, you may suddenly lose conscious as you consider Clozaril. Avoid activities in which lack of conscious might be dangerous for your requirements kinds (eg, driving, swimming, climbing, operating machinery).
• Clozaril may raise the blood glucose. High blood glucose may make you're feeling confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a very fruit-like breath odor. If these symptoms occur, tell your doctor without delay.
• Avoid munchies an excellent source of caffeine, like coffee, tea, cocoa, cola, and chocolate.
• Tell your doctor or dentist that you take Clozaril. It could influence the medical or dental hygiene, emergency care, or surgery you could receive.
• Neuroleptic malignant syndrome (NMS) is often a possibly fatal syndrome that can be a result of Clozaril. Symptoms can sometimes include fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. Contact a medical expert at once for those who have these symptoms.
• Some patients having Clozaril may develop muscle movements that they can cannot control. This is more prone to occur in elderly patients, especially women. The chance that this will happen or that it'll become permanent is greater in those having Clozaril in high doses or for a long time. Muscle problems could also occur after short-term treatment with low doses. Tell a medical expert immediately if you have muscle problems with your tongue, face, mouth, jaw (eg, tongue herniated, puffing of cheeks, mouth puckering, chewing movements), arms, or legs while taking Clozaril.
• Lab tests, including complete blood cell counts and heart function tests, might be performed to evaluate your progress or search for side effects. Be sure to keep all doctor and lab appointments.
• Use Clozaril with caution inside the elderly; they may be more sensitive to its effects, especially blood problems, dizziness (especially upon standing), fast heartbeat, urinary problems, and constipation.
• Clozaril ought to be combined with extreme care in children; safety and effectiveness in children haven't been determined.
• Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the advantages and risks of using Clozaril while you are pregnant. It is not known if Clozaril can be found in breast milk. Do not breastfeed while taking Clozaril.