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Depakote can be used to take care of various types of seizure disorders. It is sometimes used in addition to other seizure medications. It is also used to deal with the manic phase of bipolar disorders (manic-depressive illness), and also to prevent migraines. Depakote affects chemicals within the body that could be involved in causing seizures.


Use Depakote as directed from your doctor.

Ask your medical provider any queries you may have about how exactly to use Depakote.


Store Depakote between 68 and 77 degrees F (20 and 25 degrees C). Store from heat, moisture, and light-weight. Do not store inside the bathroom. Keep Depakote from the reach of kids and from pets.


Active Ingredient: Divalproex.

Side Effects

All medicines could potentially cause side effects, but some individuals have no, or minor, unwanted effects.

Check with a medical expert if some of these most common negative effects persist or become bothersome:

Change in appetite; constipation; diarrhea; dizziness; drowsiness; hair loss; headache; indigestion; nausea; stomach cramps or pain; sleep problems; vomiting; weakness; weight changes.

Seek medical assistance immediately if all of these severe side effects occur:

Severe hypersensitive reactions (rash; hives; itching; lack of breath; tightness in the chest; swelling in the mouth, face, lips, or tongue); abnormal thinking; difference in menstrual period; changes in behavior; chest pain; confusion; dark, tarry, or bloody stools; dark urine; difficulty speaking; difficulty urinating and other urination problems; extreme tiredness; fast or irregular heartbeat; hallucinations; hearing loss; involuntary movements from the arms and legs; involuntary movements or chewing movements with the face, jaw, mouth, or tongue; pain; deficiency of energy; lack of appetite; decrease of coordination; loss of seizure control; loss of memory; new or worsening mental or mood changes (eg, aggressiveness, agitation, anxiety, depression, exaggerated a sense well-being, hostility, impulsiveness, inability to sit still, irritability, panic disorder, restlessness); nosebleed; pounding inside chest; red, swollen, blistered, or peeling skin; severe or persistent nausea, vomiting, or stomach pain; breathlessness; suicidal thoughts or actions; swelling with the arms or legs; signs and symptoms of infection (eg, fever, chills, sore throat); tremor; unusual bleeding or bruising; unusual weakness; vision changes or blurred vision; yellowing with the skin or eyes.

 This is not a complete report on all negative effects that could occur. If you have questions about unwanted effects, contact your medical provider.


Do NOT use Depakote if:

Contact your physician or doctor right away if some of these apply to you.

Some medical ailments may talk with Depakote. Tell your physician or pharmacist for those who have any medical conditions, particularly if any in the following apply to you:

Some medicines may interact with Depakote. Tell your medical provider if you take some other medicines, especially any from the following:

This might not be a total report on all interactions that may occur. Ask your medical provider if Depakote may communicate with other medicines that you are taking. Check with your doctor before starting, stop, or affect the dose of any medicine.

Important safety information:

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