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Baclofen is used for treating spasm of skeletal muscles that can cause muscle clonus, rigidity, and pain on account of multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (otherwise known as striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter in the brain. Neurotransmitters are chemicals that nerves use to communicate with one another. GABA released by some nerves causes the adventure of other nerves to reduce. It is considered that Baclofen, acting like GABA, blocks the adventure of nerves within the section of the brain that controls the contraction and relaxation of skeletal muscle. Baclofen was authorized by the FDA in November, 1977.


The usual starting dose of Baclofen for adults is 5 mg 3 times daily. Based on the response, the dose can be increased gradually every three days to a maximum of 80 mg/day in numerous doses.


Baclofen should be stored between 15°C (59°F) and 30°C (86°F). Keep Baclofen out of your reach of youngsters.

Side Effects

Baclofen could potentially cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low blood pressure levels, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.

Abrupt discontinuation of oral Baclofen could cause seizures and hallucinations. Abrupt discontinuation of intrathecal Baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown).


Use of Baclofen along with other drugs which depress the function of nerves can result in additional lowering of brain function.

In addition towards the chance of depressing brain function, the application of Baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together could cause muscle weakness.

Use of Baclofen and monoamine oxidase inhibitors (e.g. Nardil, Parnate) may result in greater depression of brain function as well as low blood pressure levels.

As Baclofen can increase blood sugar levels, doses of antidiabetic drugs might need to be adjusted when Baclofen is taken.

The usage of Baclofen by expecting mothers is not evaluated.

Baclofen could be detected in the breast milk of mothers taking oral Baclofen. No info is entirely on the use of Baclofen within the breast milk of mothers receiving Baclofen intrathecally.

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