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ARAVA is indicated in adults to the treatments for active rheumatism (RA):


Take this medicine only as directed because of your doctor. Do not take really it, do not take on it more frequently, and do not take on it for a longer period than your doctor ordered.

The dose of this medicine will change for various patients. Follow your doctor's orders or the directions about the label. The following information includes just the average doses with this medicine. If your dose is unique, don't change it unless your medical professional notifys you to do this.

The level of medicine that you simply take depends for the strength with the medicine. Also, the amount of doses you take on a daily basis, some time allowed between doses, along with the amount of time you are taking the medicine depend for the problem that you are utilizing the medicine.

For oral dosage form (tablets):

For rheumatism:

If you miss a dose with this medicine, go on it as quickly as possible. However, whether it is almost time for your forthcoming dose, skip the missed dose and get back on your normal dosing schedule. Do not double doses.


Store at 25°C (77°F); excursions able to 15-30°C (59-86°F). Protect from light. Keep out from the reach of youngsters. Do not keep outdated medicine or medicine no longer needed. Store the medicine in a closed container at room temperature, far from heat, moisture.

 Keep out in the reach of children. Do not keep outdated medicine or medicine don't needed. Store the medicine in a closed container at room temperature, away from heat, moisture.


Side Effects

Stop by using this medicine and check with your physician immediately in case you are having burning, numbness, tingling, or painful sensations inside arms, hands, legs, or feet. These could be the signs of a condition called peripheral neuropathy.

Adverse reactions associated with the using leflunomide in RA include diarrhea, elevated liver enzymes (ALT and AST), alopecia and rash.

Along with its needed effects, medication might cause some unwanted effects. Although not most of these unwanted effects may occur, whenever they happen they will often need medical assistance.

Check with your medical professional immediately if any in the following negative effects occur:
More common
Bloody or cloudy urine
difficult or painful breathing
difficult, burning, or painful urination
frequent urge to urinate
loss of appetite
sore throat
tightness within the chest
yellow eyes or skin
Less common
Burning feeling in the chest or stomach
burning, prickling, or tingling sensation in the fingers or toes
chest pain
fast heartbeat
joint or muscle pain or stiffness
pounding heartbeat
severe stomach pain
lack of breath
tenderness in the stomach area
unusual tiredness or weakness
Incidence unfamiliar
Area rash
black or tarry stools
bleeding gums
blistering, peeling, or loosening of the skin
blood in the stools
burning, numbness, tingling, or painful sensations
clay-colored stools
continuing vomiting
cough or hoarseness
dark urine
fever with or without chills
general a feeling of tiredness or weakness
high fever
large, hive-like swelling for the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
small of the back or side pain
pains inside stomach, side, or abdomen, possibly radiating on the back
pale skin
pinpoint red spots on the skin
rapid, shallow breathing
red wounds, often having a purple center
red, irritated eyes
sores, ulcers, or white spots within the mouth or about the lips
swollen glands
unexplained bleeding or bruising
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting of blood
weakness inside arms, hands, legs, or feet

Some unwanted effects may occur very often tend not to need medical assistance. These unwanted effects may go away during treatment since your body adjusts on the medicine. Also, your wellbeing care professional may be able to let you know about ways to prevent or reduce some of these side effects. Check using your health care professional if any of the following unwanted effects continue or are bothersome or if you've got any queries about them:
More common
Back pain
hair loss
skin rash
stomach pain
weight loss (unexplained)
Less common
decreased appetite
dry mouth
irritation or soreness of the mouth
itching from the skin
pain or burning in the throat
runny nose

Other negative effects not listed may also happen in some patients. If you notice another effects, check with your health care professional.



It is critical that your doctor look at your progress at regular visits to make certain that this prescription medication is in working order. Blood tests may be required to test for negative effects.

Using this medicine while you're pregnant may damage your developing fetus. Use an effective kind of birth control method to hold from conceiving a child. If you think you might have get pregnant with all the medicine, tell a medical expert right away.

Leflunomide could also cause birth defects if your father is employing it when his sexual partner becomes pregnant. Men taking leflunomide should use condoms being a type of contraception during intercourse. A man going to father a young child should stop using this medicine and appearance along with his doctor right away.

Serious skin reactions can happen with this medicine. Stop employing this medicine and look with your physician straight away if you've any from the following symptoms while taking this medicine: blistering, peeling, or loosening in the skin; chills; itching; joint or muscle pain; red skin lesions, often using a purple center; sores, ulcers, or white spots inside mouth or around the lips; or unusual tiredness or weakness.

Liver problems may occur while you are utilizing this medicine. Stop applying this medicine and appearance with your doctor right away if you are having multiple of the symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; loss of appetite; feeling sick; skin rash; swelling in the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.

Leflunomide can temporarily lower the number of white blood cells in your blood, improving the chance of getting an infection. It can also lower the number of platelets, that happen to be required for proper blood clotting. If this occurs, there are specific precautions it is possible to take, specially when your blood count is low, to relieve the chance of infection or bleeding:

Check with your medical professional right away if you've a cough with or without nausea, difficulty breathing, or any difficulty with breathing.

You needs to have a skin test for tuberculosis before you start using this medicine. Tell your doctor in case you or anyone within your home has had a positive reply to a tuberculosis test.

Using this medicine may increase your likelihood of getting serious infections or cancer. Talk to a medical expert if you've concerns about this risk.

Do not take other medicines unless they are discussed with your medical professional. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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